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It is worth noting that, nuclear GSTP inhibited the association between HMGB1 and cPKC and reduced cPKC-mediated HMGB1 phosphorylation through interacting with HMGB1 in response to LPS stimulation

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However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18