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These are absolute contraindications

M., & Drfer, C

40,42 In addition, topiramate may counteract excitability that may result from elevation of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/ kainite receptor subunits in the hippocampus, orbital frontal cortex, and anterior cingulate cortex

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CMCC produced the VHR-REA_IT dataset as part of the HIGHLANDER project and released it under the CC BY 4.0 licence

This stems from intestinal damage as well as the fact that a grain-rich diet doesnt provide an adequate supply of vitamin B6