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We anticipate our algorithmic approaches will accelerate construction of large AIH cohorts to better understand and optimize initial treatment strategies for this rare disease

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Further more, DNA isolated from sera and SF of different RA patients caused appreciable inhibition in the activity of anti-CE-modified DNA antibodies clearly showing the presence of oxidatively altered epitopes on the isolated DNA molecules, which could be directly correlated to estrogen/radical mediated oxidative stress [38]

Three casecontrol studies have been conducted in women diagnosed with breast cancer, as well as women at high risk or normal risk for the disease (Fig