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Oxidative stress happens through several ways: Homocysteine goes through oxidation and auto-oxidation [18] Low folate reduces antioxidant enzyme activities, including superoxide dismutase and glutathione peroxidase [18] These changes create an environment that hurts cell function [18] Folate supplements can work as antioxidants by lowering homocysteine levels and boosting intraerythrocyte glutathione directly [19]

The human brain has a significant amount of polyunsaturated fatty acids (Sharifi-Rad et al., 2021b)

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KM: Conceptualization, Data curation, Writing original draft, Writing review & editing

doi: 10.1016/j.biomaterials.2018.01.022 97 WangB.XuY.YaoQ.SongL.LiangM.CaoH.et al