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For these cells to proliferate, a glycolytic flux needs to be constrained to allow a higher percentage of intermediates to be diverted to biosynthesis, e.g., availing G6P (glucose-6-phosphate) to the pentose phosphate pathway (PPP), thus an exquisite balance between fluxes of glycolysis and PPP that benefits tumor development

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For lipophagy, the lipid droplets coated by a double membrane structure can be observed by transmission electron microscopy

[DOI] [PMC free article] [PubMed] [Google Scholar] Huang Y, Coupland NJ, Lebel RM, Carter R, Seres P, Wilman AH, Malykhin NV