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Some of these interactions involve the upregulation of CD38, mediated by adipocyte-secreted angiotensin II (Ang II), which has been identified as the direct cause of increased expression of acetyl-CoA synthetase (ACSS2) in MM plasma cells, promoting growth by stabilizing the oncoprotein IRF4 in vitro and in vivo (95)

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Histopathology analysis On each timepoint of 1, 4, 8, 12, 14, and 18 days, three rats of each group were sacrificed

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