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Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

Guequn A, Zamorano P, Crdova F, Koning T, Torres A, Ehrenfeld P, Boric MP, Salazar-Onfray F, Gavard J, Durn WN, et al

Meunier J, Hayashi T

One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint

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Despite that low penetrance, partial deficiency of CCT in B cells resulted in decreased peritoneal and splenic B cell numbers, inducing a compromised proliferation, especially in the periphery, decreasing serum IgG concentration, and increasing the incidence of IgM-secreting cells (107)