First discovered in the 1970s, neuropeptide has since been studied for its effects on sleep cycles, mood regulation, and neuroprotection
Firstly I like how they stay on top of their schedule time
Mechanism of Action (MOA): Inhibit the DPP-4 enzyme, preventing the breakdown of endogenous GLP-1, leading to: Glucose-dependent insulin secretion Glucose-dependent glucagon secretion Efficacy: HbA1c reduction: 0.6%0.8% Primarily reduces postprandial glucose Common Dosing: Sitagliptin (Januvia): 100 mg once daily (dose adjustment required in renal impairment) Saxagliptin (Onglyza): 5 mg once daily ( dose in renal impairment) Linagliptin (Tradjenta): 5 mg once daily (no renal or hepatic dose adjustment) Alogliptin (Nesina): 25 mg once daily ( dose in renal impairment) Adverse Effects: Generally placebo-like URTI, headache, mild GI upset Advantages: Weight neutral Suitable for patients with renal impairment (with dose adjustment) Well-tolerated Possible -cellsparing effect Disadvantages: Risk of acute pancreatitis Joint pain Saxagliptin & alogliptin: potential risk of heart failure Precautions: History of pancreatitis Not recommended in DKA Not indicated in Type 1 Diabetes Monitor for heart failure (saxagliptin, alogliptin) #DPP4Inhibitors #Type2Diabetes #ClinicalPharmacy #Pharmacology #MedicationSafety #DiabetesCare #Endocrinology #PharmacyEducation #HealthcareProfessionals To view or add a comment, sign in 3,206 followers
Thats why I recommend taking B-vitamins daily, including: Vitamin B12: 200-750 mcg daily Vitamin B6: 30-40 mg daily Folic Acid: 400-800 mcg of folic acid Don't Miss Out
4c and d)
Dopamine is the neurotransmitter of motivation, reward, focus, andcruciallywakefulness
