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These results underscore the critical importance of selecting appropriate experimental models, as differences in experimental models could result in entirely opposite conclusions

Selection based on preliminary experiments For example, when the researchers selected the dose to be administered for SRS16-86, five groups were modeled as sham group, SCI group, SCI + 5 mg/kg SRS16-86 group, SCI + 10 mg/kg SRS16-86 group and SCI + 15 mg/kg SRS16-86 group, and then tested motor recovery 2 weeks after SCI to select a dose of 15 mg/kg SRS16-86 (Zhang Y

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Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders