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Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases

[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Akinola S.A., Adeyemo R.O., Binuyo M.O., Adegboyega T.T., Buhari M.O., Adebayo I.A

Preparation of Pueraria lobata root-derived exosome-like nanovesicles and evaluation of their effects on mitigating alcoholic intoxication and promoting alcohol metabolism in mice

Here we identified Lys105 of ScGrx7 and Lys26 of PfGrx as a dual activator for the catalytic cysteine residue and GSH

These bacteria have a positive effect on the production of short-chain fatty acids, especially butyrate ( Butyrate is the main energy source for colonocytes and it performs several important functions such as maintaining the integrity of the intestinal epithelial barrier, regulating mucosal immune homeostasis, suppressing colonic NF-B-driven inflammation, inducing histone deacetylase inhibition, histone acetylation, gene expression changes, epigenetic gene regulation, and promoting apoptosis in pre-neoplastic colonocytes (Figure 2 shows the main mechanisms by which various compounds of plant-based diets regulate the composition of the gut microbiota and health outcomes

A simplified schematic illustration of the progression from simple hepatic steatosis to cirrhosis is presented in Figure 2