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Following log normalization, the count data were scaled while regressing out mitochondrial reads and principal component analysis (PCA) was performed based on the 2,000 most variable features

Fluvastatin and lovastatin target the cholesterol pathway that plays a role in the prenylation of members of the PI3K/AKT/mTOR pathway and RAS, which could impact on the ability of RAS to activate BRAF [67], eventually causing a proliferation arrest

On the other hand, 22 metabolic pathways were significantly downregulated in GDH3 -deleted cells cultured in MM medium and only oxidative phosphorylation, sulphur metabolism, biotin metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis were upregulated

However, exceeding the dosage may cause nausea, abdominal cramps, a fishy body odour, and diarrhoea in some individuals

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10.1136/openhrt-2018-000993 Open Heart