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PMID: 31 ZhangXQiMHuoKCaiBZhangJTianYet al

Purohit and T

Commonly used species include rodents, such as rats, mice, guinea pigs (11) and chinchillas (12), as well as fish, notably zebrafish, and certain non-human primates, such as macaques, marmosets and monkeys (10)

The incidences of ALT and AST increases were 37% and 22%, respectively, in the omaveloxolone arm versus 2% each in the placebo arm (Table 1) [16, 20, 22]

Numerous studies have conducted phenotypic, genomic, epigenomic, transcriptomic, and proteomic analyses, utilized disease models to explore potential inhibitors, and evaluated candidate small-molecule drugs in clinical settings (115)