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10.1016/j.cmet.2010.02.006 Cell Metab

Ag Business and Economics Lauren Fritzler, Sr

UA also impedes mechanisms of drug resistance, particularly through the inhibition of ABCG2-mediated drug efflux, thereby increasing the effectiveness of chemotherapy agents

This shift may alter the absorption of many drugs, by for example increasing the ionization of weak acids like aspirin, which reduces their absorption

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HGF/c-Met pathway is one of the most dysregulated pathways in human malignancies, which include, but are not limited to: bladder, breast, cervical, colorectal, endometrial, esophageal, gastric, head and neck, kidney, liver, lung, nasopharyngeal, ovarian, pancreatic, prostate, and thyroid cancers ( Activation of Met in cancer occurs most often through ligand autocrine or paracrine activation