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We were unable to test treatments containing gemcitabine in the 3D set-up, because prolonged incubation with gemcitabine (necessary for invasion studies through collagen matrices), resulted in the death of all tumour cells on the top of the 3D matrix

This results in systemic signaling effects that extend beyond adipose tissue, making these compounds more suitable for studying integrated endocrine regulation rather than isolated metabolic pathways

Benzyl alcohol is a common issue

Our bodies do not produce vitamin B12 so we rely on getting it in our food

This will be highly patient-dependent