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A wide range of devastating human illnesses, including Alzheimers, Parkinsons, cancer, neurological disorders, and metabolic disorders, may develop in response to elevated levels of oxidative stress

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For instance, some tumours convert glutamate to KG via GLUD producing a second ammonium ion, whereas other tumours preferentially use an aminotransferase for this reaction, bypassing the production of this second ammonia, and thus suppressing autophagy

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In this sense, Yu et al