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References Hamman JJ, Kluess HA, Buckwalter JB, Clifford PS: Blood flow response to muscle contractions is more closely related to metabolic rate than contractile work

This compensatory mechanism has a profound secondary consequence: it alters the delicate balance of amino acids in the bloodstream

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Increased TMAO levels in addition to endothelial dysfunction, vascular aging, and oxidative stresses have been shown to cause thrombotic events and platelet excitability in humans, which in turn induce atherosclerosis [69, 72]

When these are introduced into a research setting, you're not just studying the peptide

Exposure to heat, light, or freezing can damage the peptide