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Although UV wavelengths match the absorption wavelength of many photosensitizers, it simultaneously poses several challenges for UV to excite materials directly for therapy as mentioned previously for prolonged UV exposure potentially causing DNA damage, immunosuppression, inflammation, photoaging and other harmful effects and finally leading to photocarcinogenesis

Lancet 353 , 814 (1999)

A disruption in the metabolism of polyunsaturated fatty acids (PUFAs), which are crucial for maintaining cellular homeostasis, will result in cellular abnormalities and an elevated risk of developing cancer resulting in angiogenesis, cell proliferation, and migration due to the synthesis of imbalanced pro- and anti-inflammatory lipid metabolites