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Rejuvenation Res 16(4):313326

Normobaric hypoxia and symptoms of acute mountain sickness: Elevated brain volume and intracranial hypertension

"Sleep circuitry and the hypnotic mechanism of GABA A drugs"

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Glutamine metabolism serves as a metabolic intersection in prostate cancer ammonium reprogramming, where this conditionally essential amino acid propels tumor proliferation through multifaceted biosynthetic and bioenergetic contributions including its catabolic flux furnishes precursors for de novo purine/pyrimidine biosynthesis and hexosamine pathway activation, drives reductive carboxylation-dependent lipogenesis, sustains redox homeostasis via glutathione synthesis and NADPH regeneration, generates non-essential amino acids, and fuels mitochondrial oxidative phosphorylation through -KG (-ketoglutarate) mediated anaplerosis, collectively establishing glutaminolysis as an indispensable axis supporting prostate cancer malignancy (25)

KvernelandAHEnevoldCDoniaMBastholtLSvaneIMNielsenCH.Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab