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Elevated systemic oxidative stress can lead to notable fibrinogen oxidation and structural alterations, which are associated with impaired fibrin polymerization and enhanced resistance to plasmin-induced lysis

Chamoun K, Kantarjian H, Atallah R, Gonzalez GN, Issa GC, Rios MB, Garcia-Manero G, Borthakur G , Ravandi F, Jain N, Daver N, Konopleva M, DiNardo CD, Kadia T, Pemmaraju N, Jabbour E, Cortes J

Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4

this is the normal way in which our bodies mount an immune response.) The people with VITT all had a very specific mutation in B cells which arose through this process