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Taking under consideration the conservative "behavior" of cysteine, the analysis of homology and alignment of related sequences usually starts with searching cysteines and locating them at appropriate positions - opposite to each other

More histamine is released as a result

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Biochem J 430:439451 Lewerenz J, Ates G, Methner A, Conrad M, Maher P (2018) Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system