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BPC 157 not only increased VEGFR2 expression in vascular endothelial cells several hours after treatment but also rapidly induced VEGFR2 internalization within minutes, subsequently activating the phosphorylation of VEGFR2, Akt, and the eNOS signaling pathway, independent of known ligands or shear stress [93]

Variation of the pattern of exposure, by including a 1.5-h break, or by additionally including eight 5-min, 6-fold higher peak exposures, did not alter the observed degenerative effects

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