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The fate of serine metabolism on macrophage polarization was investigated and a novel mechanism was proposed by which serine deficiency stimulates the M1 phenotype and inhibits STAT6-mediated M2 polarization by activating p38-dependent JAKSTAT-1 axis [286], suggesting that serine metabolism may be an underlying target

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J Gen Microbiol 138:20212028 Vermeji P, Kertesz MA (1999) Pathways of assimilative sulfur metabolism in Pseudomonas putida

doi: 10.1002/hep.28251 70 WangDTangLZhangYGeGJiangXMoYet al

These factors collectively contribute to the progressive decline in chondrocyte function and accelerated breakdown and loss of ECM(2)