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Fatigue and somatic symptoms

These foam cells induce endoplasmic reticulum stress, apoptosis and the secretion of various MMPs involved in the expansion of the necrotic core (160, 161)

Nonetheless, certain critical limitations of MSC-based therapy remain and need to be overcome before widespread clinical application becomes possible [5]

In many cases, the term drug refers to cytotoxic (chemotherapeutic) anti-cancer agents, but a broad spectrum of therapeutically active moieties can be meant

Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, et al

This work may also provide a generalizable strategy for making other gluten-degrading enzymes more stable against high heat