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Calcium Depletion Challenges Endoplasmic Reticulum Proteostasis by Destabilising BiP-Substrate Complexes

Varian Dallas IGRT Seminar

SLC7A11 presents itself as a viable target for tumor therapy, with two primary strategies currently under consideration

This metabolic adaptation, while crucial for mitochondrial function, also promotes ferroptosis in NSCLC cells under cysteine-limiting conditions, linking CHAC1 activity to cell death pathways