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Glutamine metabolism in cancer cells In cancers, glucose metabolism is primarily aerobic glycolysis, resulting in the secretion of lactate in the extracellular space [2, 27]

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These effects appear to operate through several mechanisms: Nrf2 pathway activation : Hydrogen promotes Nrf2 translocation to the nucleus, stimulating genes involved in antioxidant production Oxidative burden reduction : By neutralizing hydroxyl radicals, hydrogen may prevent depletion of other antioxidants during oxidative challenges Mitochondrial preservation : Maintaining mitochondrial function supports energy production needed for antioxidant regeneration The relationship between hydrogen and non-enzymatic antioxidants appears bidirectional

Hesketh, G