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Additionally, genetic and epigenetic variability among patients, resistance mechanisms, potential side effects, and the difficulties of translating preclinical findings to clinical applications further complicate the development of effective NRF2-targeted therapies

doi:10.1186/s12944-020-01244-4 Kostov K

GM is rich in mannose residues, which specifically bind to mannose receptors on macrophage surfaces

FOXO4-DRI + Thymalin Explored for synergistic effects on immune modulation and cellular aging

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These drugs exemplify how targeting specific virulence factors can disarm pathogens while boosting the efficacy of existing antibiotics