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(1) Direct antioxidant activity of NAC as an oxygen radical scavenger For a compound to act as an antioxidant in a biological matrix, its reaction rate with oxidants must be higher than that of endogenous antioxidants and much higher than that of the substrates present [37]

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10.1016/j.ymthe.2016.11.019 389 YanF.ZhaoQ.LiY.ZhengZ.KongX.ShuC.et al (2022a)

Mass Spectrom Rev 37(6):772792 lvarez R (2020) Non-targeted metabolomic analysis reveals serum phospholipid alterations in patients with early stages of Diabetic Foot Ulcer

Esculin can inhibit oxidative stress in liver injury, as esculin (10-40 mg/kg) can activate the Nrf2 signaling pathway to increase HO-1 expression levels and decrease the MDA content in lipopolysaccharide (LPS)/D-galactosamine-induced acute liver injury mice (61)

Some of Jerne's thinking at that time is captured by his later close collaborator Ivan Lefkovits: 'Niels realized that Burnet's clonal selection was so clear, convincing and logical that there was little to add to it