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Within the islet, extracellular insulin inhibits glucagon secretion from alpha cells, while glucagon enhances both insulin and somatostatin secretion [93]

PMID: 38117594

Lutein and zeaxanthin appear to have important antioxidant functions in the body

Most cases involve some combination of both components

Postpartum there are many stronger formulations with better pigment removing properties, but for now, consistency & compromise (safety first) is key when using pigment correctors for melasma