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Elucidation of the GSK3alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors

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the inventors have found an underlying similarity between diverse forms of iron-dependent, non-apoptotic death and that the manipulation of ferroptosis may be exploited to selectively destroy RAS-mutant tumor cells or to preserve neuronal cells exposed to specific oxidative conditions

doi: 10.1023/A:1006894909694 83 RuseMBroomeAMEckertRL

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