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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes. Mol Metab

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doi:10.3389/fphar.2015.00225

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Preclinical Studies in Diabetic Experimental Models Concerning diabetic retinopathy, in vivo studies in diabetic rats demonstrated that long-term administration of ALA exerts inhibitory effects on the development of diabetic retinopathy through inhibition of the accumulation of oxidatively modified DNA, indicating that ALA supplementation as adjunctive therapy may help prevent vision damage in patients with diabetes [64]

The two published human studies (both DAC) The pivotal human data come from a randomized, double-blind, placebo-controlled ascending-dose study by Teichman and colleagues in healthy adults