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This genetic defect is more common in South Asians and those of African origin, and unlike transcobalmin deficiency, is associated with other B12 biomarkers in the normal range and no clinical symptoms

The dual GLP-1/GIP mechanism produces sustained appetite suppression, improved glucose metabolism, and preservation of lean muscle mass during weight loss, outcomes that phentermine cannot match

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NHS treatment protocols involve intramuscular loading doses followed by maintenance therapy, with frequency determined by underlying cause and severity