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Ahmad, R

They are generally considered to have fewer side effects and be less dangerous than older-generation antidepressants, such as tricyclic antidepressants, because they specifically target the serotonin transporter, rather than affecting a wide range of neurotransmitters (Wang et al., 2018)

However, another study in the US did not replicate a large benefit

But it's important to note that the subjects received abnormally high doses (10-20g per day), and supplement users who adhere to a manufacturers recommendations are highly unlikely to come near that amount.32 Several drug-drug interactions are possible, too

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Undeniably, the contradictory results obtained from these clinical studies may have resulted from differences in adjustments for confounding factors such as the characteristics, specimen type, and study sample size of each observational study