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Researchers should always review available manufacturer documentation, published stability data, and internal laboratory procedures when preparing peptides for experimental use

[151] [152] This research subsequently led to the synthesis of the antifolate aminopterin, which was used to treat childhood leukemia by Sidney Farber in 1948

Frontiers in pharmacology , 11 , 579944

10.1097/01.brs.0000216593.97157.dd

Then alkylation would mean initiation of cancer, and the action of a carcinogen after exerting its alkylating effect, or of another nonalkylating carcinogen, would be the promotion of cancer