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Description

Peroxynitrite has a direct effect on mitochondria leading to lipid peroxidation of membrane lipids and thus damaging the complexes of the respiratory chain and mitochondrial DNA

All animals were aged for at least 12 weeks before being used in their respective experiments

Nature 535 , 440443 (2016)

Metabolic disorders, such as hyperglycemia and hyperlipidemia, can damage renal cells through oxidative stress-mediated injury, inflammatory response, apoptosis, and autophagy, leading to renal tubulointerstitial inflammation and fibrosis, glomerular hypertrophy, glomerulosclerosis and ultimately renal insufficiency [2]