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*Correspondence: Yue Deng, [email protected]

Journal of Cellular Physiology 207 (2), 331339

To support these functions, the cell maintains NAD in a largely oxidized state (NAD + ) to serve as oxidizing agent for catabolic reactions, while NADP is kept largely in a reduced state (NADPH) to readily donate electrons for reductive cellular processes (4, 6)

This is because oral supplementation might not increase cellular glutathione levels effectively, as the molecule can break down in the digestive tract before being absorbed

Some eligible studies have demonstrated the action of caffeine on glial cells through changes in GFAP and Iba-1 expression in stress-specific brain areas [27, 29]