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Growth hormone and IGF-1 may promote tumorigenesis by enhancing cell cycle progression and inhibiting apoptosis. Pollak, M., Nature Reviews Cancer IGF-1 LR3 Side Effects 1

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Extended half-life and prolonged receptor engagement: One of the defining features of IGF-1 LR3 is its structural modification that reduces binding to IGF-binding proteins

However, the relative contribution of NRF2 target genes to NRF2-dependent cancer cell proliferation is currently unknown

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