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Death typically occurred within 310 min after the start of exposure, with the exact duration influenced by factors such as body weight, age, room ventilation, and equipment

doi: 10.1001/jamaoncol.2018.4951 38 RomanoESimonRMinard-ColinVMartinVBockelSEspenelSet al

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The sponsors subsequently announced positive results from a 28-week proof-of-concept study with pramlintide and metreleptin combination treatment in overweight or obese subjects