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Second, in the 1980s, vascular endothelial cells were shown to produce nitric oxide from l-arginine, which explained the biological effects attributed to endothelium-derived relaxing factor (Furchgott and Zawadzki 1980

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Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerov D, Rayner A, Dutton L, Meier Y, Antoniou A, Stieger B, Arnell H, et al

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