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We have previously established an experimental system based on human primary fibroblasts undergoing mild and progressive ER stress upon starvation for glucose and serum (GS starvation) (Michael et al, 2023), and showed that up-regulated ATF4 and IRE1a drive the UPR and a cytokine and chemokine response (Michael et al, 2023)

doi:10.1007/s10863-015-9614-z Ortiz-Avila O, Esquivel-Martnez M, Olmos-Orizaba BE, Saavedra-Molina A, Rodriguez-Orozco AR, Corts-Rojo C (2015b) Avocado oil improves mitochondrial function and decreases oxidative stress in brain of diabetic rats

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Biotechnological approaches to producing natural antioxidants: anti-ageing and skin longevity prospects

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