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The analysis showssomewhat counter-intuitivelythat the flux responsible for the homeostasis of homocysteine is, in fact, peripheral to the methionine cycle

Additionally, astrocytes begin to show a significant increase at week 3, with astrogliosis reaching its peak during maximal demyelination occurring around weeks 56 46

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This involves the selective degradation of anti-ferroptosis proteins or organelles, such as lipid droplets, GPX4, ferritin, SLC40A1, CDH2, and BMAL1 [105, 106, 175,176,177,178,179,180]