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More recently, a 2011 trial involving more than 35,500 men over 50 found that large doses of vitamin E increased the risk of prostate cancer by 17 percent

Homocysteine is a sulfur-containing amino acid tightly involved in methionine metabolism

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Nutrients (2021) 13:2112

Complementarily, the use of preclinical assays that are not based on specific mutations models should be considered, as for example the use of iPSCs from sALS and fALS patients (with or without specific mutations) that can be differentiated in MNs, astrocytes, and microglial cells [278] and represent a valuable tool for screening different compounds [279]

Acknowledgements Authors are grateful to Panjab University, Chandigarh, India for facilities