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Serum acylcarnitines profile in critically ill survivors according to illness severity and icu length of stay: an observational study

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Interestingly, we found that only VitB12 levels were significantly increased in the insomniac group and independently associated with the presence of insomnia after adjusting for confounding factors (which differed between the two groups and have been shown to impair sleep)

The mechanistic foundation of this synergistic interaction involves tryptophan metabolism regulation and butyrate biosynthetic pathway modulation, not only ameliorating renal metabolic dysregulation but also playing pivotal roles in decelerating renal fibrogenesis progression (Han et al., 2021)