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BDNF/NGF Pathway Enhancers (Lions Mane, 7,8-DHF) Mechanism: These aim to upregulate neurotrophins or mimic TrkB signaling, nudging plasticity

Telomeres are protective caps at the ends of chromosomes that shorten during cellular replication

Common ligands include antibodies, peptides, and small molecules, with key targeting receptors such as transferrin receptor (TfR), lactoferrin receptor (LfR) and LRP-1 (Huang et al., 2024a