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although, the effect of the MOR agonist desensitizes and produces heterologous desensitization of KOR responses (KOR responses do not desensitize independent of MOR activation) (Chen et al., 2015)

Consequently, this initiates the activation of subsequent signaling routes linked to c-MET, including RAS/MAPK, PI3K/AKT, Wnt/-catenin, and JAK/STAT [3,4,5]

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