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Doses in research trials have ranged up to 2 mg per kg of body weight per day (max ~50 mg/day) to achieve therapeutic effects [5]

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Owing to its high affinity for phosphorylated ubiquitin, Parkin is easily transported from the cytoplasm to the mitochondria

Furthermore, mitochondrial 4-HNE load showed a positive correlation with activated Casp8, suggesting that the beneficial effects of Gsta4 on OL apoptosis involves mitochondrial 4-HNE load (Fig

Zong C, Xu M, Xu L, Wei T, Ma M, Zheng X, Hu R, Ren B

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