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: 1 (3-4 ) + 1 (3-4 )

Findings: Hg, Ag, Al and Ba were higher in the amalgam group but without significant differences for most of the heavy metals analyzed

doi: 10.1104/pp.84.2.218 6 DeutschJ

Taking into account the various trial status, the difference still held statistical significance after excluding all trials that began recruitment for less than 6 months at the time of analysis

It has been associated with increased BDNF and TrkB signaling in rodent brain studies, modulation of dopamine and serotonin systems, and gene-expression changes in ischemia models

Metabolite extraction To extract intracellular metabolites, cells were washed three times with dPBS and metabolites were extracted with cold LCMS grade 80:20 methanol/H 2 O (v/v)