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Cell Metab 15(6):827837 (Erratum in: 16(5):686) Mrquez J, Alonso FJ, Mats JM, Segura JA, Martn-Rufin M, Campos-Sandoval JA (2017) Glutamine addiction in gliomas

The darker you are

Some patients benefit from one or the other depending on their lab results and symptoms

Autophagic degradation of ferritin in cytoplasm or lysosome, known as ferritinophagy, could lead to elevated intracellular iron levels, thereby accumulating ROS and eventually triggering ferroptotic cell death (Hou et al., 2016)

As an extension of the above, the brains high metabolic rate and oxygen consumption make it vulnerable to oxidative stress, which can lead to aging and neurodegenerative diseases like Alzheimers and Parkinsons Disease