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Similarly, in nonsmall cell lung cancer (NSCLC), NOX4-derived ROS from tumor cells drive M2 polarization through the PI3K/AKT pathway [142]

Mammalian lipoxygenases and their biological relevance

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doi: 10.1016/j.apt.2020.03.004 237 Mohammadi-AlouchehRHabibi-YangjehABayramiARahim PouranSLatifi-NavidSAsadiA

GHK-Cu also increases activity of antioxidant enzymes and can potentially neutralize harmful byproducts created during oxidative stress