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These effects were associated with the inhibition of NF-B nuclear translocation and reduced phosphorylation of B and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase (282)

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Cells received via Yale University were cultured with RPMI-1640 (Gibco, 11875093) that was supplemented with 10% fetal bovine serum (FBS) (Cytiva, SH30071.03HI-LSF), 1% streptomycin-penicillin (Gibco, 15140122), and 0.3% amphotericin B (Gibco, 15290018)

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While controlled angiogenesis is essential for proper wound repair, the excessive growth of blood vessels can lead to delayed wound closure, the remodeling of affected tissues, or other complications during the healing process