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Furthermore, serum copper concentrations differ among patients with different carotid atherosclerotic plaque morphologies

Together, these cascades orchestrate the initiation and resolution of inflammation

However, parameters had different intensities of effects

Zhu Y, Shao Y, Qu X, Guo J, Yang J, Zhou Z

However, in NDDs, chronic or overwhelming ER stress shifts the UPR toward maladaptive responses, contributing to neuronal dysfunction and death, e.g., Prolonged PERK activation has been implicated in AD, PD, and ALS, where it contributes to chronic ER stress and neuronal death